Miriam Bujny
Chief Development Officer Sapreme Technologies
Seminars
Friday 23rd January 2026
Maximising Cytosolic Delivery of Oligonucleotides Through Endosomal Escape
11:00 am
- Evaluating intracellular sequestration of oligonucleotides in endosomes and uptake by glial or immune cells to understand limitations in target neuron bioavailability
- Exploring ligand and conjugate strategies, including lipid, peptide, and antibody modifications, to improve endosomal escape and cytosolic delivery
- Linking escape efficiency to dosing, safety, and disease-specific biology to optimise therapeutic index across neuro targets
NEW DATA
