Guillaume Hautbergue

Founding Director & Chief Scientific Officer Crucible Therapeutics

Seminars

Friday 23rd January 2026
Advancing SRSF1-Interfering Genetic Therapies for the Treatment of C9orf72-ALS/FTD & Other Neurodegenerative Diseases
3:30 pm
  • Strategies to identify emerging genetic targets beyond the crowded IP space and evaluating their therapeutic potential with different oligonucleotide modalities
  • Overcoming preclinical translation challenges by leveraging humanized and disease-specific models to confirm target relevance, address species-specific phenotypes, and predict clinical efficacy
  • Integrating bioinformatics and AI-driven approaches to prioritise causal targets, enhance mechanistic validation, and accelerate the selection of disease-relevant candidates  

NEW DATA

Guillaume