Beatriz Llamusí Troísi

Participants will examine innovative strategies to improve CNS penetration beyond transferrin receptor approaches, optimise molecular functionalisation for active transport, and leverage predictive models and organoid technologies to accelerate development while minimising systemic exposure and toxicity. The session will highlight practical insights for designing shuttles that balance deep brain delivery, regional specificity, and safety as the field prepares for clinical translation.

Highlights Include:

• Explore second-generation BBB shuttles to improve CNS penetration and regional specificity
• Design oligo conjugates for active transport without compromising activity
• Maximise brain delivery while minimising systemic exposure and off-target effects
• Use organoids, lab-on-chip, and in silico models to accelerate development
• Efforts to apply AI and machine learning to streamline shuttle design and reduce experimental trial-and-error
• Combine chemistry, dosing, and delivery strategies to achieve safe and effective CNS therapeutics