Roundtable Discussion: Enhancing CNS Oligonucleotide Efficacy Through Neuron-Specific Delivery & Cell Type Precision Formulation
- Evaluate strategies to preferentially deliver oligonucleotides to neurons compared with glial populations to maximise pharmacodynamic impact and therapeutic precision
- Discover how lipid conjugates, peptides, and other targeting modalities modulate intracellular trafficking, regional CNS distribution, and cell specific internalization
- Measure tissue and cellular exposure early in preclinical studies to distinguish effects driven by chemistry from those driven by target biology and guide rational design for selective CNS engagement