Roundtable Discussion: Designing CNS Oligo Dose Regimens: From High Loading Dose to Safe Chronic Maintenance
- Design dosing strategies around CNS distribution and target engagement, using high initial doses for deep regions and maintenance dosing to sustain effect
- Select administration routes based on risk-benefit, balancing invasiveness, BBB penetration, and systemic toxicity
- Integrate PK/PD modelling, molecular design, and delivery devices to maximise efficacy while maintaining safety for chronic CNS therapy