• Evaluating intracellular sequestration of oligonucleotides in endosomes and uptake by glial or immune cells to understand limitations in target neuron bioavailability
• Exploring ligand and conjugate strategies, including lipid, peptide, and antibody modifications, to improve endosomal escape and cytosolic delivery
• Linking escape efficiency to dosing, safety, and disease-specific biology to optimise therapeutic index across neuro targets

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