From Preclinical Evidence to Early Clinical Studies: Advancing VO659 for Polyglutamine disorders

  • Development of VO659: outlining the path from candidate selection through IND-enabling activities and entry into Phase 1/2a studies
  • Broader implications of the VO659 program for advancing next-generation oligo therapies targeting CNS disorders
  • Beyond VO659: innovating ASO chemistry to improve CNS uptake